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    STUDIA PHYSICA - Issue no. SPECIAL ISSUE / 2001  
         
  Article:   PROTON NMR SPECTROSCOPY STUDIES OF THE INCLUSION COMPLEX OF NIFLUMIC ACID WITH  - CYCLODEXTRIN.

Authors:  M. BOGDAN, S.I. FARCAS, MINO R. CAIRA. 		 
       
         
  Abstract:  The inclusion complex of niflumic sodium salt with -cyclodextrin has been studied by proton NMR at 300 MHz. The continuous variation technique was used to evidence the formation of a 1:1 complex in aqueous solution at pH = 12. The association constant of the niflumic Na salt with -cyclodextrin has been obtained at 298 K, by fitting the experimental chemical shift difference, obs = obs - free, (for a given proton) of the observed guest or host molecule, with a non-linear regression method. Besides the effective association constant, the fitting procedure allows a precise determination of all NMR parameters of the pure inclusion complex which are used for an analysis of the geometry of the molecular edifice in solution.  
         
     
         
         
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