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    STUDIA PHYSICA - Issue no. 2 / 2008  
         
  Article:   13C CPMAS NMR STUDY OF CHLORTHALIDONE AND FUROSEMIDE INCLUSION IN Β-CYCLODEXTRINS.

Authors:  BOGDAN FRENŢIU, CODRUŢA ŞOICA, CRISTINA DEHELEAN, ÁRPÁD GYÉRSESI, MIHAELA ALUAŞ, S. SIMON. 		 
       
         
  Abstract:  The nuclear magnetic resonance (NMR) spectroscopy on solids using cross-polarization magic angle spinning experiment have been used to study insertion of drugs chlorthalidone in hydroxypropyl-β-cyclodextrin (HPBCD) and furosemide in randomly methylated β-cyclodextrin (RAMEB) to see if exist any interaction between substances in each case, and if they will shape inclusion complexes. Both drugs are practically in water insoluble diuretic, used for the treatment of edema and hypertension. The preparations have been done in 1:1 and 1:2 molar ratios using specifically methods like kneading product and ultrasonication. The study demonstrate that HPBCD and RAMEB are able to include in their cavities chlorthalidone and furosemide respectively, follow by formation of inclusion complexes with a high bioavailability, offering possibility to produce new improved pharmaceutical products.

Key-words: NMR spectroscopy, furosemide, chlorthalidone, RAMEB, HPBCD. 		 
         
     
         
         
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