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    STUDIA PHYSICA - Issue no. 1 / 2008  
         
  Article:   PHYSICAL CHARACTERIZATION OF SOME MUCOADHESIVE GELS FOR ORAL CAVITY APPLICATIONS.

Authors:  ELENA DINTE, M. TODICA, C.V. POP, SORIN E. LEUCUŢA. 		 
       
         
  Abstract:   The influence of formulation on rheological characteristics of bioadhesive buccal gels based on polyacrilic acid (Carbopol 940) and carboxymethylcellulose sodium (CMCNa) was investigated. The flow behaviour, the consistency and the spreading capacity of these gels were evaluated. The rheograms obtained corresponded to some tixotropic gels with pseudo plastic or plastic behavior. The increase of the polymer ratio in the gel content led to the increase of the yield stress and the decrease of the maximum penetration degree and of the spreading surface. The results obtained showed that Carbopol 940 had a predominant effect on the rheologic characteristics of these gels.

Keywords: bioadhesive buccal gels hydrophil polymers metronidazole rheology 		 
         
     
         
         
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