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    STUDIA CHEMIA - Issue no. Special Issue / 2010  
         
  Article:   PREPARATION AND MODELLING OF THE STRUCTURE OF TRANSFERRIN-Fe3+-AZIRIDINE-CARBOXYLATE COMPLEX.

Authors:  . 		 
       
         
  Abstract:  The absorption of the iron ions by the cells is realised through a transport protein, the transferrin, via receptor mediated endocytosis. The presence of a synergistic anion (which in vivo is the bicarbonate) is crucial for stabilizing the iron-binding site of human serum-transferrin. This efficient cellular uptake pathway has been exploited for the site-specific delivery of anticancer drugs. We substituted bicarbonate with another synergistic anion, the aziridine carboxylate, which possesses cytotoxic effect against the cancer cells. Using in silico methods we determined, that this substitution has no significant change in the polypeptide folding or domain orientation in the structure of human serum transferrin.

Keywords: human serum transferrin, iron uptake, synergistic anion, in silico method 

  
         
     
         
         
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