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Authors: LAURIAN VLASE, SORIN E. LEUCUŢA, FLORIN DAN IRIMIE.
A simple, fast and sensitive LC/MS/MS method for quantification of ibuprofen and pseudoephedrine in human plasma has been developed and validated. The lower limit of quantification was established at 0.05 μg/ml IBU and 5 ng/ml PSE. Ibuprofen and pseudoephedrine were separated under isocratic conditions on a Zorbax RX C18 column (3.0 x 100mm, 3µ).
Keywords: ibuprofen, pseudoephedrine, LC/MS/MS, bioequivalence
