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The glucocorticoid-induced tumor necrosis factor (TNF) receptor (GITR) is a member of the TNF receptor superfamily. GITR is expressed in T lymphocytes and in natural killer cells (NK). The receptor it is activated by its ligand, GITRL, which is a type II transmembrane protein. Human tumor cells express substantial levels of GITRL. GITRL attachment to its receptor blocks antitumoral effects of NK cells. As human tumor cells constitutively express GITRL, the presence of it can be used as a potential tumor marker. In this study the pETM50-hGITRL expression vector was constructed for heterologous expression of the ligand in a bacterial system.

Keywords: tumor necrosis factor, GITR, GITRL, expression vector, regulatory T cell