AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary
The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name.
Authors: ANDREEA ELENA MIRON (LUNGU), MARIOARA MOLDOVAN, DOINA PRODAN, MIHAELA VLASSA, MĂDĂLINA MOLDOVAN, RAREȘ CĂLIN ROMAN, MÎNDRA EUGENIA BADEA.
DOI: 10.24193/subbchem.2020.4.05
Published Online: 2020-12-30
Published Print: 2020-12-30
pp. 63-72
VIEW PDF: FULL PDF
ABSTRACT: Polymers represent a novel alternative in bone regeneration. Polydioxanone combined with Pluronic was used as a carrier for Oxytocin in form of an interfacial deposition obtained scaffold. The low rate of resorption of the scaffold follow the bone regeneration sequence assuring a constant and continuous release of Oxytocin. The Oxytocin release was monitored by RP-HPLC method. The separation was performed on a Phenomenex Luna 5µm C18 100A, 250x4.6mm, using isocratic elution with acetonitrile: phosphate buffer pH 7 (30:70 v/v) mobile phase. Flow rate 1 ml / min, column temperature 30°C, DAD, = 220nm. The surface morphology of polydioxanone - pluronic 127 - Oxytocin impregnated mesh was characterized by SEM. The preliminary results show that the Polydioxanone combined with Pluronic is a promising polymer for bone regeneration engineering.
Key words: polydioxanone, Oxytocin, bone reconstruction, biodegradable scaffolds, RP-HPLC, SEM
