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    STUDIA CHEMIA - Issue no. 4 / 2011  
         
  Article:   RAMAN AND SERS CHARACTERIZATION OF NORMAL PATHOLOGICAL SKIN.

Authors:  CRISTINA DEHELEAN.
 
       
         
  Abstract:  This study presents a Raman characterization of normal pathological mice skin both in vivo and ex vivo. Good correlation between the in vivo acquired spectra from the back of the mice specimens and the ex vivo formalin fixed skin samples was observed, although the in vivo spectra presented better resolved Raman bands. Additionally, using near-infrared laser excitation SERS spectra were acquired from the ex vivo skin samples immersed in Ag nanoparticles. The NIR-SERS spectra revealed main vibrational modes at 1573, 1327, 1227 and 227 cm-1 preponderantly characteristic to nucleic acids, which bring additional contribution to the chemical composition of the Raman investigated tissue.

Keywords: Raman, SERS, mice skin, in vivo
 
         
     
         
         
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