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    STUDIA CHEMIA - Issue no. 3, Tom II / 2016  
         
  Article:   INFLUENCE OF TABLET FORMULATION ON IN VITRO RELEASE OF MAGNESIUM.

Authors:  OANA CADAR.
 
       
         
  Abstract:  The transfer of active substances of pharmaceutical forms is influenced by several factors, among which the nature of the excipients used in compression. The objective of this study was to investigate the influence of cellulose and its derivatives (hydroxypropylcellulose, hydroxylpropylmethylcellulose, carboxymethylcellulose) on the release profile of magnesium from marketed tablets (T1-T4). In vitro release experiments were carried out using a dissolution apparatus, in ultrapure water and simulated intestinal fluid (pH=6.8). In selected formulations, the amount of magnesium released was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The magnesium dissolution profiles demonstrated complete dissolution for T1, even just after 5 min. Magnesium release rate decreased with the increase in cellulose and/or its derivatives proportion: T1T3T2T4. An agitation speed of 50 rpm showed a more satisfactory magnesium release profile than 100 rpm.

Keywords: magnesium release, in vitro, pH, matrix tablet
 
         
     
         
         
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