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    STUDIA CHEMIA - Issue no. 3, Tom I / 2016  
         
  Article:   CYTOTOXIC ACTIVITY OF PALLADIUM (II) COMPLEXES OF (1E,6E)-1,7-BIS(4-(DIMETHYLAMINO) PHENYL)HEPTA-1,6-DIENE-3,5-DIONE AGAINST HUMAN COLON CARCINOMA.

Authors:  NATALIA MIKLÁŠOVÁ, ROMAN MIKLÁŠ, PIROSKA VIRAG, CORINA BIANCA TATOMIR, CRISTINA SZALONTAI, DIANA CENARIU, FERDINAND DEVÍNSKY, EVA FISCHER-FODOR. 		 
       
         
  Abstract:   Two palladium(II) complexes of (1E,6E)-1,7-bis(4-(dimethilamino) phenyl)hepta-1,6-diene-3,5-dione were synthesized and structurally characterized with the aim of testing their cytotoxicity towards human colon tumor cells in vitro. Complexes A and B have the capacity to inhibit the cell growth in HT-29 and DLD-1 cell lines, the activity of A being superior as a result of a better accumulation inside the tumor cells.

Keywords: palladium complexes, curcumin derivative, cytotoxicity, colon cancer, cellular uptake
 
         
     
         
         
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