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    STUDIA CHEMIA - Issue no. 3 / 2015  

Authors:  .
  Abstract:   DNA-electrochemical biosensors allow rapid detection of hazard compounds interaction with dsDNA with great sensitivity. The application of the DNA-electrochemical biosensor for the detection of DNA oxidative damage by hazard compounds and pharmaceutical drugs, namely by hydroxyl free radicals, in situ generated at the boron doped diamond electrode surface, the hepato-toxins microcystine-LR and nodularine, the temozolomide, the nucleoside analogue gemcitabine, the anticancer disubstituted triazole-linked acridine compounds, and the anticancer antibody rituximab, showing current directions and strategies, will be revisited.

Keywords: DNA, oxidative damage, electrochemistry, biosensor, cancer.
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