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    STUDIA CHEMIA - Issue no. 3 / 2011  
         
  Article:   SPECTROSCOPIC INVESTIGATION OF ANTI-BACTERIAL AGENTS ACTIVITY.

Authors:  VITALY ERUKHIMOVITCH, IGOR MUKMANOV, MAHMOUD HULEIHEL. 		 
       
         
  Abstract:  FTIR spectroscopy has been widely used in recent time as a efficient tool to biomedical investigations. In this study we examined the potential of FTIR microspectroscopy as analytical instrument for early evaluation of anti-bacterial therapy efficiency. For this purpose, the effect of propolis (PE) on the development of bacterial infection in cell culture was examined. PE is a natural honeybee product with a potent anti-bacterial activity. Our results show early (2h post treatment) unique and significant spectral indicators for successful treatment with PE. Some of these biomarkers demonstrate different trends in gram (-) compared to gram (+) bacteria. It seems that FTIR spectroscopy can be used as an effective analytical tool for an early evaluation of the efficiency of the anti-bacterial effect of PE and probably other used drugs.

Keywords: FTIR microscopy; Bacteria; Propolis 		 
         
     
         
         
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