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    STUDIA CHEMIA - Issue no. 2, Tom I / 2019  
         
  Article:   HETEROCYCLES 50. SYNTHESIS AND CHARACTERIZATION OF NEW 2-PHENYLAMINOTHIAZOLE DERIVED MANNICH BASES BY BIOCATALYTIC MULTICOMPONENT REACTIONS.

Authors:  DENISA LEONTE, ROBERT TŐTŐS, VALENTIN ZAHARIA. 		 
       
         
  Abstract:  In this work we describe the synthesis and characterization of new Mannich bases derived from 2-phenylaminothiazole, by applying the trimolecular condensation of thiazole aldehydes with aniline and acetone, catalyzed by lipase B from Candida Antarctica. The target compounds were obtained with 68-76% yields, in mild and eco-friendly reaction conditions. The new heterocyclic Mannich bases were characterized by melting points, 1H NMR, 13C NMR and MS spectrometry.

Keywords: thiazole, Mannich base, lipase, multicomponent reactions 		 
         
     
         
         
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