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	STUDIA CHEMIA - Issue no. 2, Tom I / 2019

	Article:	SYNTHESIS OF 3-AMINO-7-ARYL-8-AZACHROMANS: VALIDATION OF A SYNTHETIC ROUTE WITH ENANTIOSELECTIVE POTENTIAL. Authors: EDUARD BADARAU, FRANCK SUZENET, ADRIANA-LUMINITA FINARU, GERALD GUILLAUMET.


	Abstract: A potential enantioselective access to 3-amino-7-aryl-8-azachromans is described. The reported multi-step synthesis involved the use of aspartic acid as the building block that could induce chirality. The azachroman scaffold was obtained via a key intramolecular inverse Diels-Alder cycloaddition between a 1,2,4-triazine and a judiciously functionalized alkyne. This class of compounds are hetero-isosteres of previously reported ligands of the histaminergic H₃ receptor. Keywords: 8-azachroman, inverse Diels-Alder cycloaddition, H₃R ligands




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