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    STUDIA CHEMIA - Issue no. 2, Tom I / 2019  
         
  Article:   CONTINUOUS-FLOW ENZYMATIC KINETIC RESOLUTION MEDIATED BY A LIPASE NANOBIOCONJUGATE.

Authors:  MĂDĂLINA ELENA MOISĂ, LÁSZLÓ CSABA BENCZE, CSABA PAIZS, MONICA IOANA TOŞA. 		 
       
         
  Abstract:  This study describes the development of a continuous-flow procedure for the enzymatic kinetic resolution of rac-1-phenylethan-1-ol with the clickable acylating agent 2,2,2-trifluoroethyl 2-(prop-2-yn-1-yl-oxy)acetate, which allows facile click reaction-based downstream, enabling the large-scale chemo-enzymatic synthesis of both secondary alcohol stereoisomers with high enantiopurity. The influence of flow rate, acylating agent and substrate concentration upon the productivity of the packed-bed reactor was investigated. In addition to this, the performances of continuous-flow and batch reactors were compared.

Keywords: enzymatic kinetic resolution, secondary alcohol, lipase, continuous-flow process, batch process, productivity 		 
         
     
         
         
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