AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: ARIADNA PĂUN, LAURA MONICA RUSU, MĂRIOARA MOLDOVAN, SORINA SAVA, ALEXANDRA DREANCA, CECILIA BACALI, MÎNDRA EUGENIA BADEA, CRISTINA BORZAN, IOANA BÂLDEA.
DOI: 10.24193/subbchem.2023.2.06
Published Online: 2023-06-30
Published Print: 2023-07-30
pp. 85-97
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The aim of this study is to identify and test new natural photosensitizers used in antibacterial photodynamic therapy due to the antimicrobial and antioxidant effect they present. The experimental study was conducted on rats in which periodontal disease was induced. As treatment, photodynamic therapy was used in the presence of new developed natural photosensitizers based on oregano essential oil and curcumin extract. Malondialdehyde as well as low and oxidized glutathione levels were measured by spectrophotometry to assess oxidative stress in treated groups of rats. New photosensitizers were characterized by modern testing methods, using FTIR infrared spectroscopy, gas chromatography-mass spectrometry and UV-Vis analysis. The results obtained suggest that the prooxidant effect is mainly due to exposure to photodynamic therapy (irradiation) and leads to the antibacterial therapeutic effect that is maintained even when applying gels with antioxidant agents.
Keywords: Oxidative stress, essential oils, photodynamic therapy
