AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: VICTORIA CÎRJEU, CRISTINA PUȘCAȘ, RADU SILAGHI-DUMITRESCU.
DOI: 10.24193/subbchem.2021.2.28
Published Online: 2021-06-30
Published Print: 2021-06-30
pp.325-332
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ABSTRACT: The anticancer drug vincristine, known to act by inhibiting tubulin function in human cells, is shown to affect autoxidation rates in hemoglobin – either alone or under conditions where nitrite acts as an initiator in a nitrosative stress cascade. This behavior mirrors those observed by us with four other antitubulin agents - irinotecan, docetaxel, paclitaxel and vinorelbine.
Key words: vincristine, hemoglobin, autoxidation, nitrite, oxidative stress, nitrosative stress, UV-vis
