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Authors: ALEXANDRA FĂLĂMAȘ, SIMONA CINTĂ PÂNZARU, CRISTINA DEHELEAN, MONICA M. VENTER.
Autopsy skin tissues collected from mice specimens exposed to UVB irradiation and 7,12-dimethylbenz(a)anthracene were immersed in formalin solution mixed with colloidal silver nanoparticles and analyzed using Raman imaging. The aim of this study was probe the SERS technique applied to tissue analysis, to detect the main molecular components present in the investigated organs and to search for a new way of acquiring enhanced Raman signal from these tissues for early diagnostic. The analysis of the collected spectra indicated chemisorption of the nanoparticles into the tissue and the possibility to record high quality SERS signal.
Keywords: Raman imaging, tissue SERS, skin cancer, mouse model, silver nanoparticles
