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Authors: ZENO GÂRBAN, ADINA-ELENA AVACOVICI, GABRIELA GÂRBAN, FRANCISC PETER, GEORGE-DANIEL GHIBU, MIRCEA BOTOCA, ALIN CUMPĂNAŞ.
Biogenesis of lithiasic concrements constitutes a special domain when taking into account the location of lithiasis (currently named calculi or stones) in the organism, e.g.: sialolithiasis, rhinolithiasis, urolithiasis, flebolithiasis a.o. as well as the type of lithiasis.
In case of purine metabolites of endogenous (strictly metabolic) and exogenous (foods) origin the concrements formation in urine implies a heterogenous nucleation mechanism where metallic ions participate, too.
Problems concerning the purine uroconcrements (mainly with uric acid) and their content in alkaline and alkaline-earth metals were approached by investigations based on physico-chemical methods. Thus, by Fourier Transform - Infrared Spectroscopy the types of urolithiasis and by atomic absorption spectroscopy the metallogram (Na, K, Ca and Mg) of purine urolithiasis were established.
Keywords: purine metabolism and uroconcrements; alkaline and alkaline-earth metals in purine uroconcrements
