AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: ALHAGIE JADAMA, SEDA YUKSEKDANACI, DEMET ASTLEY, IHSAN YASA.
DOI: 10.24193/subbchem.2023.1.06
Published Online: 2023-03-27
Published Print: 2023-04-30
pp. 75-89
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Schiff and azo-Schiff base derivatives were synthesized, identified and evaluated for their antimicrobial and antifungal activities against gram-positive bacteria, gram-negative bacteria and fungi such as Escherichia coli, Pseudomonas aureginosa, Staphylococcus aureus, Bacillus cereus, Salmonella typhimurium, Saccharomyces cerevisiae and Candida albicans. Chiral amides (2a-e) were synthesised by using D-Phenylglycine, L-Phenylalanine, L-valine, L-isoleucine and L-methionine. Experimental studies include the use of chiral amide derivatives (2a-e) of the five amino acids to synthesize the Schiff and azo-Schiff base derivatives of amides (3a-e, 4a-c and 4e). The structures of the compounds were determined by spectroscopic analyses (FTIR, 1H-NMR, 13C-NMR) and elemental analysis. Among the tested compounds, compound 3b and 3d were found to show the most potent inhibitory action against Gram positive and Gram negative bacteria.
Keywords: Schiff base, azo-Schiff base, amino acid, amide, biological activity
