AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: MIHAELA-CĂTĂLINA HERGHELEGIU, AUDE ERNAULT, MIHAIL SIMION BELDEAN-GALEA, MARIA-VIRGINIA COMAN.
DOI: 10.24193/subbchem.2023.1.02
Published Online: 2023-03-27
Published Print: 2023-04-30
pp. 19-35
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The widespread use of paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) make them increasingly present in environmental factors, especially in water. The aim of this work was to develop an accurate, precise and sensitive analytical procedure for the simultaneous determination of Paracetamol and four NSAIDs (Ketoprofen, Naproxen, Diclofenac, and Ibuprofen). To this aim, the extraction (liquid-liquid extraction, LLE, and solid-phase extraction, SPE) as well as the chromatographic (high-performance liquid chromatography-photodiode array detector, HPLC-PDA, and gas chromatography-mass spectrometry in selected ion monitoring mode, GC-MS-SIM) techniques, in terms of the performances were compared. Different extraction solvents and types of cartridges at pH 3 of samples were tested for the extraction optimization. Low limits of detection and quantification at the g/L level were achieved. The developed HPLC-PDA and GC-MS-SIM methods were applied to the analysis of selected pharmaceuticals in different wastewater samples.
Keywords: paracetamol and NSAIDs, solid-phase extraction, liquid-liquid extraction, GC-MS, HPLC-PDA
