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    STUDIA CHEMIA - Issue no. 1 / 2005  
         
  Article:   THE IDENTIFICATION BY MS AND GC/MS OF PHOTODEGRADATION PRODUCTS OF INDOMETHACIN OINTMENT.

Authors:  VASILE MICLĂUȘ, ILDIKÓ BROŞ, ZAHARIE MOLDOVAN, CLAUDIA CIMPOIU, EMANOIL SURDUCAN, NICOLAE PALIBRODA.
 
       
         
  Abstract:  This paper reports the photo degradation of indomethacin from a pharmaceutical cream formulation. For the determination of the degradation compounds a MS analysis was performed by direct introduction of the sample in high vacuum and a GC separation of the components. Mass spectra of electronic impact (EI) in GC-MS were also registered. Six compounds, which held the indomethacine moieties, were identified.  
         
     
         
         
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