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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name. |
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STUDIA BIOLOGIA - Issue no. Sp. issue / 2015 | |||||||
Article: |
THE RISK FOR COLORECTAL CANCER AND POLYMORPHISMS OF APC GENE. Authors: OANA ANDRADA ALEXIU, MIHAI TOMA, IRINA RADU, ANNE-MARIE CRĂCIUN, DĂNUȚ CIMPONERIU. |
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Abstract: VIEW PDF: THE RISK FOR COLORECTAL CANCER AND POLYMORPHISMS OF APC GENE Colorectal cancer (CRC) is a complex genetic disease which appears as a result of interactions between multiple genetic and non-genetic factors. In this study we have analyzed the association between four polymorphisms of APC gene (rs41116, rs465899, rs2229992 and rs2019720) and colorectal cancer in Romanian population. After receiving the informed consent, blood samples were obtained from individuals with CRC (M:F=95:85) and from healthy persons (M:F=27:33). Genomic DNA was extracted from peripheral blood samples and the APC gene polymorphisms were assessed by PCR-RFLP. The promoter polymorphism rs2019720 was associated with CRC. Thus, the CC genotype (OR 2.307) and allele C (OR 1.843) increased the disease risk, while the AA genotype (OR 0.453) and allele A (OR 0.543) decreased the CRC risk. We found that the APC polymorphism rs2019720 was associated with CRC in Romanian population. Keywords: Adenomatous polyposis coli, colorectal cancer, polymorphisms |
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