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    STUDIA BIOLOGIA - Issue no. 2 / 2009  
         
  Article:   THYROGLOBULIN IN THE EVALUATION OF NODULAR GOITRE AND THYROID CARCINOMA.

Authors:  COSMIN LISENCU, DOINA PICIU, ALEXANDRU IRIMIE, ADELA BARA, ALEXANDRINA ROMAN, CLAUDIU PESTEAN. 		 
       
         
  Abstract:  The number of patients with nodular goitre and thyroid carcinoma worldwide has increased, mainly after Chernobyl nuclear accident. Thyroglobulin is reported as an essential tumour marker in the management of patients with differentiated thyroid carcinoma. The aim of the study was to determine the thyroglobulin level in the thyroid tissue obtained by fine needle aspiration from thyroid nodules or cervical lymph nodes and to improve the specificity of the method in the diagnosis of cancer. In this retrospective study we used the database of the Institute of Oncology “Prof. Dr. I. Chiricuţă” in Cluj-Napoca (Romania) from the decade 1998-2007; a number of 1803 cases of malign thyroid tumors with the mean age of 47 years and 15,778 cases of nodular goitre with the mean age of 42.1 years. We analyzed the evolution of the incidence of this pathology. We performed 600 fine needle aspirations; among them we selected 35 cases with the serum and also the tissue level of thyroglobulin determined on electrochemiluminescence method. We analyzed the results and the correlation between the serum thyroglobulin, tissue thyroglobulin, their ratio with serum, the total protein and the histological results after the surgery. The conclusion of the study was that a simple and very accessible method, such as fine needle aspiration, could improve the differential diagnosis of thyroid nodules.

Keywords: nodular goitre, thyroglobulin, thyroid carcinoma
  
         
     
         
         
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