AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name. |
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STUDIA BIOETHICA - Issue no. 1-2 / 2014 | |||||||
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EXPERIMENTAL MODELS FOR THE STUDY OF LIVER FIBROSIS. Authors: CRISTIAN CEZAR LOGIN, ADRIANA MUREȘAN, MARIA ALUAȘ, SIMONA CLICHICI. |
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Abstract: Liver fibrosis represents a possible reversible lesion observed in a large number of chronic hepatic injuries. Frequently, liver fibrosis quantification is performed using invasive maneuvers. Identification of non-invasive fibrosis markers, which might allow a quick and specific diagnosis for the fibrosis onset and, equally, which might allow monitoring fibrosis progression is very important. Research can be performed on experimental models, using rats or mice. In order to induce fibrosis, invasive techniques can be used (e.g. biliary ducts ligation), as well as, frequently, toxic experimental models. The experimental model to be used should be chose by taking into account how invasive the method is, how many animal will be used, the toxicology of the used substance, how reproducible the model is, and the extent to which the results of the experiment can be used in clinical research. The article will present the most frequently chronic experimental hepatitis models used, the ethical challenges and the legal issues concerning the use of animals for research in Romania. Keywords: toxic hepatitis, experimental model, carbon tetrachloride, thioacetamide |
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