AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name. |
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STUDIA AMBIENTUM - Issue no. 1-2 / 2008 | |||||||
Article: |
THE IMPORTANCE OF SOME NON-TARGETTED CELLULAR EFFECTS IN ASSESSING THE LUNG CANCER RISK INDUCED BY RADON AND ITS PROGENY. Authors: LUCIA-ADINA TRUŢĂ-POPA, WERNER HOFMANN, CONSTANTIN COSMA. |
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Abstract: Until about two decades ago, there was a dogma in radiation sciences that biological effects appear only in case of direct irradiation of cells, when energy deposition occurs in the nucleus of the cell. Lately, a different approach than the deterministic relationship “hit-effect” model was adopted in radiobiology, in favor of some concepts regarding the responses at the cellular level. At low doses of exposure to ionizing radiation a number of delayed, non-targeted effects of cells not directly hit by radiation were reported. In this study, a mechanistic model was proposed, for estimating the lung cancer risk induced by direct and particularly indirect biological cellular effects that occurred after exposure to alpha particles. The objective of the present study was to explore the role of non-targeted cellular radiation effects on the shape of the dose-effect curve in the low dose region, i.e. to investigate whether mechanisms such as bystander effects and adaptive response will increase or decrease lung cancer risk shape at radon exposure levels characteristic of residential exposures. Keywords: non-targeted effects, lung cancer, risk, bystander, adaptive response |
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