AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
|
|||||||
Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI În partea de jos este prezentat rezumatul articolului selectat. Pentru revenire la cuprinsul ediţiei din care face parte acest articol, se accesează linkul din titlu. Pentru vizualizarea tuturor articolelor din arhivă la care este autor/coautor unul din autorii de mai jos, se accesează linkul din numele autorului. |
|||||||
STUDIA BIOLOGIA - Ediţia nr.2 din 2011 | |||||||
Articol: |
EVALUATION OF THE INHIBITORY EFFECTS OF STATINS ON BLOOD VESSEL DEVELOPMENT – PROSPECTS FOR ANTIANGIOGENIC THERAPY OF CANCER. Autori: RAMONA MARIA MAXIM, MARIUS COSTEL ALUPEI, SEPTIMIU TRIPON, MANUELA BANCIU. |
||||||
Rezumat: Statins have a primary activity related to cholesterol lowering in cardiovascular diseases. Besides their main pharmacological action, statins have pleiotropic activities with possible harmful effects on processes associated with tumor development: angiogenesis, inflammation, and metastasis. The present work has shown the effects of statins on formation of blood vessels in a chicken chorioallantoic membrane (CAM) model in vivo. Statins have been selected based on their potency to reduce cholesterol levels in blood in the following order simvastatin> lovastatin> pravastatin. The inhibitory effects of statins on vasculature development might be a promise for their future application in anticancer antiangiogenic therapy. Keywords: angiogenesis, CAM assay, statins |
|||||||