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    STUDIA PHYSICA - Issue no. 1 / 2003  
         
  Article:   PHOTOPHYSICAL PARAMETERS FOR EL-4 CELLS INACTIVATION IN PHOTODYNAMIC THERAPY OF CANCER.

Authors:  RODICA-MARIANA ION, LUCIA SAVI, G. SAVI, V. I. R. NICULESCU. 		 
       
         
  Abstract:  Photodynamic therapy (PDT) of tumor is an indirect method for cancer treatment by the combined action of oxygen, light and different photosensitizers-drugs, porphyrins being the most used between them. Several parameters for porphyrin dyes, used as sensitizers for PDT aluminum porphyrin tetrasulphonate with different axial ligands C2, C4, C8 and C12, are evaluated in this paper, as follows: • absorption, fluorescence-excitation and fluorescence-emission spectra of the cell-bound dyes; • relative quantum yields for photoinactivation of EL-4 cells (prelevated from singenic mice C57 Bl/6) after 18 hours incubation with the dyes; • relative quantum yields of photodegradation of the singlet oxygen trap-1,3-diphenylisobenzofuran (DPBF) in cells after 18 h incubation with the dyes; • data processing with Fast Fourier Transform for singlet oxygen quantum yield; • partition coefficients in 2-octanol-water system.  
         
     
         
         
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