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    STUDIA CHEMIA - Issue no. Special%20Issue%202 / 2009  
         
  Article:   ASYMMETRIC BIOTRANSFORMATIONS IN CONTINUOUS FLOW REACTORS.

Authors:  LÁSZLÓ POPPE.
 
       
         
  Abstract:  

Asymmetric acetylations of prochiral diols 3a-d with isopropenyl acetate were investigated with different commercial and self prepared lipases. Continuous flow mode reactions were performed in small stainless steel packed-bed reactors which can precisely control temperature (-10-200 °C), pressure (0-150 bar) and flow rate (0.1-3.0 mL/min). The effect of the temperature and flow-rate on the conversion and enantiomer excess of the chiral monoesters was investigated.

 

Keywords: lipase, continuous flow reactor, asymmetric biotransformation

 
         
     
         
         
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