AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: CLAUDIU RĂCHIERIU, DAN T. ENIU, EMIL MOIŞ, FLORIN GRAUR, CARMEN SOCACIU, MIHAI ADRIAN SOCACIU, NADIM ALHAJJAR.
DOI: 10.24193/subbchem.2020.4.15
Published Online: 2020-12-30
Published Print: 2020-12-30
pp. 203-215
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ABSTRACT: Lipidomics is an advanced analytical technology applying techniques like Gas- or Liquid Chromatography coupled with Mass Spectrometry or Magnetic Resonance Spectrometry to find the lipid biomarkers in tissues, blood or urine. This review selected significant results which show the impact of lipidomic investigations for discriminating the metabolic profiles and dysregulation of metabolic pathways in CRC patient’s comparative to healthy controls. It focuses on the description of best methods and procedures to separate and identify hydrophobic molecules with molecular weights under 1000 Daltons, especially using high pressure liquid chromatography coupled with mass spectrometry. The main lipid classes involved in the onset and progression of CRC are presented, as well the alterations of lipid-related cellular pathways during tumorigenesis. Especially lipid profile changes (of cerotic acid, hydroxylated, polyunsaturated fatty acids, free fatty acids, oxylipins, glycero¬phospholipids, di- and triglycerides, sphingomyelins and ceramides) showed significant differences and can be considered reliable biomarkers to discriminate between early and advanced stages of CTC malignancy, prognosis or survival prediction.
Key words: metabolomics, lipidomics, colorectal cancer, biomarkers.
