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    STUDIA CHEMIA - Issue no. 4 / 2019  
         
  Article:   MULTIVARIATE CALIBRATION METHOD FOR SIMULTANEOUS ESTIMATION OF FLUOCORTOLONE CAPROATE, FLUOCORTOLONE PIVALATE AND CINCHOCAINE HCL IN SUPPOSITORY.

Authors:  ÖZLEM AKSU DÖNMEZ.
 
       
         
  Abstract:  
DOI: 10.24193/subbchem.2019.4.09

Published Online: 2019-12-20
Published Print: 2019-12-30
pp. 121-130
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In this paper, the simultaneous quantitative assay of Fluocortolone caproate (FCC), Fluocortolone pivalate (FCP) and Cinchocaine HCl (CIN) in suppository has been reported as a simple alternative analytical method. A partial least squares (PLS-2) regression was used for resolution of the overlapped spectrophotometric signals from mixtures of the three drugs. A calibration set containing FCC, FCP and CIN was constructed by using 33 full factorial design in the concentration range of 4.5-8.5, 5-7 and 8-12 μg/mL, respectively. Absorption spectra were recorded in the range 240-350 nm. To check the quality of the proposed method, it was applied to the determination of these compounds in synthetic mixtures and pharmaceutical formulation, suppository. The PLS-2 method yielded recoveries ranging from 91 to 106%. The results compared well with those from the reported HPLC method.

Keywords: fluocortolone caproate, fluocortolone pivalate, cinchocaine HCl, PLS
 
         
     
         
         
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