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    STUDIA CHEMIA - Issue no. 4 / 2016  
         
  Article:   LIPASE CATALYZED PARALLEL KINETIC RESOLUTION OF IBUPROFEN .

Authors:  BOTOND NAGY, MӐDӐLINA ELENA MOISӐ, ALINA FILIP, LÁSZLÓ CSABA BENCZE, MONICA IOANA TOȘA.
 
       
         
  Abstract:  VIEW PDF: Lipase Catalyzed Parallel Kinetic Resolution of Ibuprofen

A series of commercially available lipases in various solvents using several alcohols as nucleophiles were studied for the stereoselective esterification of ibuprofen and alcoholysis of ibuprofen esters respectively. Novel methods were developed for the stereoselective synthesis of both enantiomers of the target compound. The (S)-selective alcoholysis and (R)-selective hydrolysis in a parallel kinetic resolution procedure in presence of lipase from Mucor miehei as catalyst were performed.

Keywords: lipase, Ibuprofen, enzymatic kinetic resolution, stereoselectivity

Published Online: 2016-12
 
         
     
         
         
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