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    STUDIA CHEMIA - Issue no. 4 / 2013  
         
  Article:   ANALYSIS OF THE AEROSOL TRANSPORT AND TOPOLOGY OF THEIR DEPOSIT IN THE LUNGS VIA CFD TECHNIQUE IN NONSTATIONARY FLOW CONDITIONS.

Authors:  . 		 
       
         
  Abstract:   Therapy of lung pathology, based on the active aerosols, is one of the most efficient ways of treatment when aerosols are delivered directly into the area where the disease is installed. Only in this way the medical practice could be optimized. Predicting the behavior of a particular device for aerosol delivery and/or describing accurately the aerosol transport and deposition along the respiratory tract represent the key for achieving a successful and modern medical practice. The problem of modeling and simulation of aerosol behavior along the pulmonary tract has not been solved yet. A more detailed knowledge of the mechanisms of aerosol deposition in different parts of the respiratory tract during breathing cycles is necessary and essential in establishing different therapeutic strategies for drug delivery via aerosol particles. Accordingly, the aim of this paper was to investigate, through modern means, the aerosol transport and deposition along the respiratory tract in non-stationary conditions. CFD and CAD techniques have been employed for simulating regional deposition of particles, as functions of aerosol characteristics, ventilation parameters, and respiratory system morphology. The mathematical approach for airflow simulations over the pulmonary tract considered a modified k-ε model with incorporated non-stationary features. Simulations were made for single and multiple respiratory cycles, in order to identify the transport and exact aerosol deposition topology along the pulmonary airways. The results reveal the topology of aerosol deposition zones along the 3D computational domain and the characteristics of the air-aerosol mixture flow. 

Keywords: CFD, aerosol transport, lung topology, unsteady-state simulation
 
         
     
         
         
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