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    STUDIA CHEMIA - Issue no. 3 / 2014  
         
  Article:   INVESTIGATION OF DNA BINDING AND CLEAVAGE ACTIVITIES OF BORON COMPLEXES IN THE PRESENCE OF HYDROGEN PEROXIDE.

Authors:  . 		 
       
         
  Abstract:   Magnesium [di(hydroxy)mono(citratoborate)]dihydrate (Mg[B(Cit)(OH)2]2.2H2O), Lithium [di(hydroxy)mono(citratoborate)]hydrate Li[B(Cit)(OH)2].H2O, Sodium [di(hydroxy)mono(salicylato) borate)hydrate Na[B(Sal)(OH)2].H2O and Magnesium[bis(salicylatoborate)]decahydrate Mg[B(Sal)2]2.10H2O) complexes have been synthesized and characterized. The cattle genomic DNA (CG-DNA) interaction of the complexes was studied by spectroscopic methods, viscosity, and electrophoresis measurements. The complexes partially intercalated to CG-DNA. Furthermore, DNA cleavage activity of these complexes was also investigated using agarose gel electrophoresis and the complexes show moderate ability of cleavage to the DNA. 

Keywords: Boron complexes, DNA-binding cleavage, DNA cleavage
 
         
     
         
         
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