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    STUDIA CHEMIA - Issue no. 3 / 2011  
         
  Article:   CYCLODEXTRINS AND SMALL UNILAMELLAR LIPOSOMES: A COMPARATIVE THEORETICAL APPROACH.

Authors:  CORINA COSTESCU, LAURA CORPAŞ, NICOLETA GABRIELA HĂDĂRUGĂ, DANIEL IOAN HĂDĂRUGĂ, ZENO GÂRBAN. 		 
       
         
  Abstract:  Cyclodextrins and liposomes are generally used for protecting and controlled release of bioactive compounds. This is the first attempt to compare the cavity characteristics of cyclodextrins and small unilamellar liposomes by using molecular modeling techniques. The volume of the liposome cavity was 524 Å3. In the case of β cyclodextrin this cavity volume was only 87 Å3, but with a slightly higher molecular volume (878 Å3). As a conclusion, the smaller unilamellar liposome (theoretically modeled) could encapsulate bioactive compounds 5-6 fold bigger than β-cyclodextrin, while bioactive compound/cyclodextrin/liposome systems could be also obtained.

Keywords: liposome, β-cyclodextrin, molecular modeling 		 
         
     
         
         
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