AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: EMŐKE RÉDAI, IZABELLA RÁDULY, ZOLTÁN-ISTVÁN SZABÓ, ADRIANA CIURBA, NICOLETA TODORAN, PAULA ANTONOAEA, ROBERT-ALEXANDRU VLAD, PÉTERFI ORSOLYA, EMESE SIPOS.
DOI: 10.24193/subbchem.2021.2.25
Published Online: 2021-06-30
Published Print: 2021-06-30
pp.287-297
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ABSTRACT: The aim of this experimental work was the enhancement of water solubility of the lipid lowering drug, atorvastatin, by embedding it in polymer based micro-sized fibers, prepared by electrospinning. Characterization of the fibrous mats included morphological investigations, determination of drug content, disintegration time, small volume dissolution- and DSC studies. The electrospinning process was continuous without droplet formation. The obtained fibers were homogenous, continuous filaments with smooth surfaces. Average fiber diameters were slightly above 1 µm, while disintegration of fiber mats upon contact with water was almost instantaneous (three to ten seconds). Dissolution of the lipid lowering drug was almost complete, when using a solution feed rate of 1 mL/h.
Key words: atorvastatin, electrospinning, PVP, microfibrous mats
