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    STUDIA CHEMIA - Issue no. 1-2 / 2001  
         
  Article:   A CHITOSAN/CARBOXYMETHYLCELLULOSE COMPLEX USED FOR THE PH-CONTROLLED DELIVERY OF CEFTRIAXONE.

Authors:  N. AELENEI, M. CHIRITA, I.M. POPA, DELIA AELENEI, DANIELA ANDREI, GABRIELA CARJA. 		 
       
         
  Abstract:  Ceftriaxone is a parenteral third generation cephalosporin antibiotic owing a typical “zwitterion” molecule, containing both basic and acidic radicals. Due to the specific structure this drug forms stable complexes with both polyanionic macromolecular compounds - as carboxymethylcellulose (CMC) and polycationic macromolecular compounds - as chitosan. Consequently, a chitosan/CMC/ceftriaxone complex can be obtained and used for the controlled release of the drug, the release rate being strongly influenced on the pH.. The optimal chitosan/CMC combination ratio was determined spectrophotomrtrically. An insoluble chitosan/CMC/Ceftriaxone complex, containing 17% ceftriaxone, was prepared. The kinetic of ceftriaxone release was analyzed as a function of the elution medium pH. The experimental data point out that the maximum quantities of the released ceftriaxone are obtained after 200 min at pH=1.95 and pH=11.75, and after 1600 min at pH=4.68, pH=5.74, pH=6.54 and pH=7.34. The maximum quantity of drug released from the complex is strongly dependent on the pH, being closed by 100% in strong acidic and basic solutions, while it becomes only approximately 5% at pH = 6.54. This behaviour was explained by the intricate structure of the complex.  
         
     
         
         
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