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    STUDIA CHEMIA - Issue no. 1-2 / 2001  
         
  Article:   SYNTHESIS OF NEW ALKYLANTS WITH ESTERS OF N-(M-AMINOBENZOYL)-L-ASPARAGIC ACID SUPPORT.

Authors:  CRISTINA BĂSU, V. ŞUNEL, M. POPA, LĂCRĂMIOARA BĂLĂIŢĂ-RUSU, DOINA SÂRBU.
 
       
         
  Abstract:  In order to obtain new antitumoural compounds acting as alkylating agents, some esters were synthesized, to the - and -carboxylic group of the N-(m-aminobenzoyl)-L-asparagic acid. These esters were then converted into di-(-hydroxyethyl)-amino compounds by condensation with ethylene oxide in a diluted acetic acid medium. By substituting the chlorine for the hydroxylic groups the corresponding di-(-chloroethyl)-amino compounds were obtained.  
         
     
         
         
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