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    STUDIA CHEMIA - Issue no. 1-2 / 2000  
         
  Article:   INTERACTION OF PROCAINE WITH BIOMEMBRANES.

Authors:  JANOS ZSAKO, MARIA TOMOAIA-COTIŞEL, AURORA MOCANU.
 
       
         
  Abstract:  Compression isotherms of stearic acid (SA), dipalmitoyl phosphatidylcholine (DPPC), distearoyl phosphatidylcholine (DSPC) and of cholesterol (C) monolayers, as well as of mixed DPPC and C films have been recorded both in the absence and the presence of procaine. The penetration of procaine molecular species from the aqueous subphase into the lipid monolayers has been studied. By using Gibbs equation, penetration numbers were derived from compression isotherms. Results are discussed in terms of molecular conformations, hydrophilic and hydrophobic interactions, allowing an insight into the molecular mechanism of procaine binding and penetration into the insoluble lipid monolayers studied.  
         
     
         
         
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