AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: ADRIAN BOGDAN ȚIGU, ALIN IULIAN MOLDOVAN, CRISTIAN SILVIU MOLDOVAN, SABINA POJAR, RAREȘ DRULA, CLAUDIU TRAIAN JULA, DIANA GULEI, MADALINA LORENA NISTOR, BIANCA PATRICIA MOLDOVAN, CLAUDIU ȘTEFAN MIRESCU, CORINA LUMINIȚA ROȘIORU.
The economic impact of diagnosing, treating and monitoring diabetic patients is huge, for both patients and medical systems involved. Adequate diets are hard to follow especially in poor countries, and stress life significantly contributes to diabetes development. In addition, access to relevant treatment may be limited for many patients and some medical policies do not help. Dietary supplements are a key to help patients raising their quality of life, to alleviate symptoms and in some cases, to reduce insulin doses. 40 adult male Wistar rats were used, divided in 4 groups of 10 animals each: Control (C), Diabetic (D), Diabetic Lycopene (DL) and Diabetic Spirulina (DS). Diabetes was induced with a single dose of streptozotocin (50 mg STZ/kg body weight) in the tail vein. The DL group was given 10 mg lycopene/kg/day, while the DS group received 200 mg phycocyanin/kg/day in the form of Arthrospira (Spirulina) powder containing 15% phycocyanin. Treatment with Arthrospira powder reduced the activity of seric alanine aminotransferase (ALT) and seric aspartate aminotransferase (AST) in diabetic animals (DS). Serum catalase (CAT) activity in the DS group was significantly reduced, compared to both C and D groups. Hepatic CAT activity in both treated groups increased as compared to the control and diabetic group. Furthermore, phycocyanin and lycopene stimulated serum and hepatic lactate dehydrogenase (LDH) activity in DL and DS rats. Some other effects of lycopene and Spirulina powder, such as lowering blood and hepatic cholesterol concentrations and normalizing the histological structure of brain, liver, kidney and pancreatic tissues, support the assumption that both compounds have a potential therapeutic role as adjuvants.
Keywords: diabetes, lycopene, phycocyanin, streptozotocin
