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    STUDIA BIOLOGIA - Issue no. 2 / 2005  
         
  Article:   METABOLIC OUTCOME OF RAPAMYCIN ADMINISTRATION IN TYPE 1 DIABETES MELLITUS.

Authors:  GIANLUCA PERSEGHIN, LUCIA PICENI-SERENI, CAMELIA LANG, LIVIO LUZI. 		 
       
         
  Abstract:  In order to asses metabolic effects of rapamycin, 9 insulin-dependent diabetic patients were studied in the basal postabsorbtive state and during euglycemic hyperinsulinemia, before (PRE) and after (POST) 45 days of rapamycin administration. Labelled glucose and leucine were infused to asses whole-body rates of glucose metabolism and proteolysis. In the basal state, POST demonstrated with respect to PRE: (a) lower glucose plasma concentration (226.92 ± 30.72 vs. 293.15 ± 17.11mg/dl; p ≤ 0.05); (b) higher plasma c-peptide (0.06 ± 0.01 vs. 0.04 ± 0.00 ng/ml; p ≤ 0.05) and leucine concentration (175.08 ± 17.44 vs. 134.25 ± 9.30 µmol/l; p ≤ 0.05), and (c) similar MCR (1.82 ± 0,17 vs. 1,65 ± 0,10 mg/kg/min) and ELF (138,41 ± 11,08 vs. 131,26 ± 10.61 µmol/kg/h). During hyperinsulinemia, rapamycin did not affect in any way hepatic glucose production and muscle proteolysis. The results of present study indicated that rapamycin (1) in the absence of insulin is able to lower plasma glucose concentration by enhancing residual insulin secretion; (2) rapamycin tends to emphasize diabetic catabolic state through stimulation of proteolysis (3) in insulin stimulated condition, rapamycin ameliorated muscle insulin resistance through enhancing glucose uptake.  
         
     
         
         
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