AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: FRANCIS AIBUEDEFE IGIEBOR, FAVOUR CHINAZA MICHAEL, OCHOYAMA HARUNA, BECKLEY IKHAJIAGBE.
DOI: 10.24193/subbbiol.2024.1.04
Article history: Received 24 November 2023; Revised 19 February 2024; Accepted 16 May 2024; Available online 30 June 2024.
©2024 Studia UBB Biologia. Published by Babeş-Bolyai University.
pp. 87-106
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Plant-based nanoparticles offer sustainable, eco-friendly alternatives to conventional methods, promising antibacterial properties in the face of antibiotic resistance and addressing global health concerns. Five urine and stool samples were collected from the Benin Medical Centre in Benin City, Edo State, and sent to the Wellspring University Research Laboratory for microbiological analysis. Carica papaya and Bryophyllum pinnatum were used for fresh utilization by washing, weighing, and crushing their leaves, then mixing them with distilled water and heating at 85 °C and 60 °C for 60 minutes. Silver and copper nanoparticles (AgNPs and CuNPs) were synthesized using standard procedures. The NPs were preliminary validated by visual detection of color changes and characterized using a UV-visible spectrophotometer at 300 nm and Fourier transform infrared. The in vitro antimicrobial activity of plant-mediated NPs was investigated using five isolates: S. aureus, B. alvei, H. pylori, P. aeruginosa, and E. coli. The in vitro antimicrobial activity of plant-mediated NPs was investigated using five clinical strains displaying multiple resistance to antibiotics: S. aureus, B. alvei, H. pylori, P. aeruginosa, and E. coli. The agar-well diffusion method showed inhibition of the isolates by plant-mediated NPs but no inhibition by the plant extract alone. The study indicates that plant-mediated NPs exhibit promising antimicrobial activity, promoting sustainability and eco-friendliness, but further research is needed to assess their safety and efficacy in clinical settings.
Keywords: nanoparticles, resistant, antimicrobial, plant-mediated, MAR index.
