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The present paper intends to introduce a opinionated understanding of the patient-physician communication in the context of research and experimental practice. Some aspects need to be taken into account, as conditions that cannot be overloaded in a patient-physician relationship: 1. the physician as researcher and as clinician; 2. the difference of perspectives and interests between patient and physician; 3. the influence of the non-knowledge (Sartre) on the patient-physician relationship; 4. their different experience. The paper argues the following. First, the asymmetry that distinguishes the patient-physician relationship should to be seen as a resource, contrary to the common opinion that tends to avoid it; second, precisely the process through which informed consent is obtained, if correctly understood, can be a privileged instrument which preserves the quality of this relationship.

Keywords: patient-physician relationship, non-knowledge, asymmetry in the patient-physician relationship, informed consent