AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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STUDIA CHEMIA - Ediţia nr.2 din 2009 | |||||||
Articol: |
HIGH-THROUGHPUT DETERMINATION OF IVABRADINE FROM HUMAN PLASMA BY LC/MS/MS AND ITS APPLICATION TO PHARMACOKINETIC STUDIES. Autori: LAURIAN VLASE, DANA MUNTEAN, SORIN E. LEUCUŢA, IOAN BÂLDEA. |
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Rezumat: A rapid, selective, sensitive and reproducible liquid chromatographic method with mass spectrometric detection (LC-MS/MS) has been developed and validated for the analysis of a bradycardic agent, ivabradine, in human plasma. The samples (0.2 ml) were precipitated using perchloric acid 7% (0.1 ml) and the centrifuged supernatants were injected into HPLC system. Separation and detection of ivabradine were achieved using a C18 column and an MS/MS detector, with a positive electrospray ionization source. The ion transition monitored was 469→(177 262). Ivabradine gave a linear response ranging from 0.49 ng/ml to 49.30 ng/ml. The lower limit of quantification was established at 0.49 ng/ml. The analyte demonstrated good short-term, post-preparative and freeze-thaw stability. The validated method was subsequently applied to a pharmacokinetic study of ivabradine tablets on healthy volunteers. Keywords: ivabradine, pharmacokinetics, LC-MS/MS, human plasma |
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